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Is the polymorphism of mthfr a psychiatric risk factor?


Asked by Katherine Nelson on Dec 09, 2021 FAQ



However, it is unclear whether the polymorphism of MTHFR could be an independent or an add-on risk factor for specific psychiatric symptoms, such as anxiety, depression, positive, or negative symptoms of schizophrenia, or acts as risk factor for specific psychiatric disorders, such as schizophrenia, major depression, autisms, and bipolar disorders.
Just so,
Increasing evidence demonstrated that MTHFR polymorphism including C677T and A1298C is associated with psychiatric diseases. The MTHFR gene polymorphism is linked to onset, clinical symptoms, prevalence as well as response to treatments.
Also Know, MTHFR variants and elevated homocysteine levels have been studied as risk factors for a number of health conditions. When thinking about risk factors it is important to not only think about if the variants put you at risk for a condition, but if so, how much risk. You will find many studies on MTHFR and health risks.
Keeping this in consideration,
People with common MTHFR variants can have normal or elevated levels of homocysteine in their blood or urine. MTHFR variants and elevated homocysteine levels have been studied as risk factors for a number of health conditions.
One may also ask,
The encoding of MTHFR appears to be polymorphic such as the gene site C677T, one of the most studied and clinically important variant in exon 4. The C677T variant results from a single nucleotide substitution at this position, in which cytosine is replaced by thymine resulting a conversion of alanine to valine residue 24.